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Ruscoe JE, Rosario LA, Wang T, Gat L, Arifoglu P, Wolf CR et al
R The most common slow alleles are NAT2*5B (rs1801280, Ile114Thr), NAT2*6A (rs1799930, Arg197Gln), and NAT2*7B (rs1799931, Gly286Glu)
The pro-inflammatory phenotype of macrophages from diabetic foot ulcer patients is primarily caused by increased binding of accumulated phenylpyruvic acid to PPT1, which inhibits depalmitoylation activity and promotes NLRP3 palmitoylation and stability, which in turn activates the NLRP3 inflammasome and releases inflammatory factors ( 5 Conclusion and perspective As a dynamically reversible post-translational modification of proteins, S-palmitoylation serves as a central hub for mediating downstream signaling pathways by precisely regulating the subcellular localization, conformation, stability, and molecular interaction networks of key proteins in inflammatory signaling pathways